Biomarkers and trajectories of sleep duration and disturbance in Understanding Society
|Day:||Thu 4 Jul|
Sleep duration and quality are associated with adverse health outcomes. The mechanisms are not well understood but may involve processes related to metabolic, inflammatory or iron metabolism. However, studies are predominantly cross sectional and require replication. This study assessed associations between metabolic markers (BMI, waist circumference, glycated hemoglobin, dehydroepiandrosterone sulfate (DHEAs)), inflammation (C-reactive protein (CRP), fibrinogen) and iron status (hemoglobin, Hb) and changes in sleep duration and disturbance in 15,090 participants of Understanding Society: UK Household Longitudinal study (UKHLS). Longitudinal latent class analysis of sleep measures collected at three time points in 8 years revealed 5 classes of sleep duration and 8 classes of sleep disturbance. Adverse levels of BMI, waist circumference, HbA1c, DHEAs, fibrinogen and Hb were associated with short sleep duration trajectory compared to the 7h sleep class (for example DHEAs: log odds of short sleep membership by standard deviation increase:-0.05 (95% confidence intervals -0.08, -0.01). Biomarkers were predominantly independently associated with trajectories of sleep characterized by subsequent deterioration of sleep or chronic sleep disturbance compared to no sleep disturbance. Metabolic and inflammatory markers are independently associated with short sleep duration and increasing sleep disturbance. That the majority of biomarkers examined are associated, may indicate that non-normative sleep duration reflects poor underlying health. Metabolic and inflammatory markers may precede adverse changes in sleep disturbance and thus have a potential to play a role in the association of sleep disturbance and poor health.